Clean particular folders periodically with free software Autodelete.  If you forgot to clean up particular folders at time then this Autodelete software is useful to clean the files in a particular folder.

You can set any folders to delete the content. For example if you want to delete temporary files just select target folders by browsing (C:\Documents and Settings\username\Local Settings\Temp) and set delete files older than 1 day. This setup will delete the contents in the Temporary folder when its older than 1 day.

Download Clean particular Folders from Box.net